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KMID : 0356919920250040719
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Korean Journal of Anesthesiology
1992 Volume.25 No. 4 p.719 ~ p.725
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Effects of Halothane, Enflurane and Isoflurane on Hepatic Function in Children
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Abstract
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The effects of halothane. Enflurane and isoflurane on the postoperative hepatic functions were compared in 91 pediatric patients with normal preoperative hepatic functions. After induction of anesthesia with thiopental and vecuronium, all the
patients
were randomly divided into three groups of halothane(n=31), enflurane(n=27) and isoflurane(n=33.) Anesthesia was maintained with 1 MAC of each anesthetics combined with N2O(50%) and O2(50%).
On the postoperative lst day(POD#1), we observed elevated total bilirubin in each groups, which was normalized on the postoperative 2nd day(PDO#2). Intergroup comparisons were not significant. SGOT was elevated on the POD#1, but returned to
normal
on
the POD2 in halothane and isoflurane groups. SGPT showed no changes postoperatively. SGOT and SGPT were not significant between the groups. Alkaline phosphatase showed significant decrease on the POD#2 in enflurane and isoflurane groups. Which
was
statistically significant compared with halothane group.
This study shows that halothane. Enflurane and isoflurane has no harmful effects on the postoperative hepatic functions, when they are administered in the pediatric patients with normal preoperative hepatic functions.
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